Abstract
Being one of the largest diseases impacting human health, cancer has necessitated further anti-tumor drug research. As a result the 9 aminoacridine has been evaluated for its anti cancer tumor properties. These compounds are known as DNA intercalates since they bind to DNA and induce apoptosis. The goal of this research is to synthesize a bromine substituted derivative O-phenyl-N-(9’-acridinyl)-hydroxylamine, a novel 9 aminoacridine. Since bromine is deactivating but also has two lone pairs, the effects the substituent will have on the drug are unclear and to be evaluated further. The drug will be created using a substituted N-phenyloxythalmide and chloroacridine.
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The Purpose of This Research
The purpose on this research is to expand on the research done by Matthew DeSelm, where he eliminated a carbon - oxygen bond in a existing 9-aminoaciridne compound. Our goal is to further this research by adding a bromine substituent to the compound. This way the drug will not only be less susceptible to hydrolysis but will also have a slightly strengthened bond the DNA. The figure to the left shows the compound in question.
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